ABSTRACT
Objective Depression and obesity are two major disorders associated with coronary heart disease ( CHD) , and both have a high prevalence. Different studies concluded different outcomes about the relation between body mass index ( BMI) and depression. The aim of this study was to assess the status of depression and investigate the relationship between de-pression and BMI in CHD patients using quantile regression. Methods 580 patients were enrolled. Depression was tested using the Zung Self-Rating Depression Scale ( SDS) . Demographic data and clinical data were recorded. Quantile regression was con-ducted to determine whether BMI was a predictor of depression. Results SDS scores were significant different in underweight, normal weight,overweight and obesity group (P<0. 001). Overweight and obesity patients were least depressed. Differences in SDS scores increased steeply as depression increased at 5th,10th,25th,50th,75th,90th and 95th percentiles,with the coefficients ranging from -0. 36 to -0. 88 in total population,-0. 26 to -1. 09 in male and -0. 46 to -0. 75 in female respectively. The effects of BMI on depression were significantly different in different quantiles of depression in total population ( P=0. 04 ) and in male (P=0. 006),but no difference in female. Conclusion There was also a phenomenon of "obesity paradox" between BMI and depression in CHD patients. The effects of BMI on depression were significantly different in different quantiles in total population and in male.
ABSTRACT
Objective Depression and obesity are two major disorders associated with coronary heart disease ( CHD) , and both have a high prevalence. Different studies concluded different outcomes about the relation between body mass index ( BMI) and depression. The aim of this study was to assess the status of depression and investigate the relationship between de-pression and BMI in CHD patients using quantile regression. Methods 580 patients were enrolled. Depression was tested using the Zung Self-Rating Depression Scale ( SDS) . Demographic data and clinical data were recorded. Quantile regression was con-ducted to determine whether BMI was a predictor of depression. Results SDS scores were significant different in underweight, normal weight,overweight and obesity group (P<0. 001). Overweight and obesity patients were least depressed. Differences in SDS scores increased steeply as depression increased at 5th,10th,25th,50th,75th,90th and 95th percentiles,with the coefficients ranging from -0. 36 to -0. 88 in total population,-0. 26 to -1. 09 in male and -0. 46 to -0. 75 in female respectively. The effects of BMI on depression were significantly different in different quantiles of depression in total population ( P=0. 04 ) and in male (P=0. 006),but no difference in female. Conclusion There was also a phenomenon of "obesity paradox" between BMI and depression in CHD patients. The effects of BMI on depression were significantly different in different quantiles in total population and in male.
ABSTRACT
Objective To investigate the value of early?phase enhancement ratio combined with peripheral vascular diameter in the differential diagnosis of benign and malignant breast lesions using 3.0 T dynamic contrast?enhanced magnetic resonance imaging (DCE?MRI). Methods Sixty seven cases of patients (35 with malignant lesions and 32 with benign lesions in the breasts) were retrospectively analyzed. Their diagnoses were confirmed by surgery and pathology and all the patients underwent breast MRI plain scan and DCE?MRI in the two weeks before surgery. Lesion ROIs were drawn and time?signal intensity curves in the DCE?MRI were generated. Early?phase enhancement rate, time to peak, early?phase enhancement ratio, numbers of tumor vessel within 3 cm of the lesion and diameter of the largest vessel were recorded. Mann?Whitney U test was used to compare the difference of DCE?MRI between benign and malignant lesions, and the ROC curve was used to evaluate the efficiency of early?phase enhancement rate, early?phase enhancement ratio and vascular diameter in differentiating benign and malignant lesions. Results With breast malignant lesions, the medians of time to peak, early?phase enhancement rate, early?phase enhancement ratio, numbers of tumor vessel and vascular diameter were 2.2 s, 176.0%, 100.0%, 4 and 2.96 mm respectively, while with benign lesions of these parameters were 4.7 s, 113.3%, 81.9%, 0 and 0.00 mm respectively, and the differences were statistically significant (all P<0.05).When early?phase enhancement rate was used for differential diagnosis of breast benign and malignant lesions, the area under the ROC curve was 0.702 and the sensitivity and specificity were 82.86%and 56.25%with a threshold of 120.0%. When early?phase enhancement ratio was used, the area under the ROC curve was 0.854 and the sensitivity and specificity were 94.29% and 68.75% with a threshold of 86.0%. When peripheral vascular diameter was used, the area under the ROC curve was 0.896 and the sensitivity and specificity were 74.29%and 84.38% with a threshold of 2.78 mm. When early?phase enhancement ratio was combined with peripheral vascular diameter, the area was 0.925 and the sensitivity and specificity were 97.14% and 62.50%. Conclusion In the differential diagnosis of benign and malignant breast lesions under DCE?MRI, early?phase enhancement ratio combining with peripheral vascular diameter has improved sensitivity.
ABSTRACT
Objective To evaluate the diagnostic value of intra-arterial thrombi under went susceptibility weighted imaging(SWI) in patients with acute ischemic stroke(AIS).Methods The MRI images of 133 patients with AIS was analyzed,included time of flight MR angiography(TOF-MRA )and SWI.The patients were divided into two groups according to the time between onset of symptoms and MR imaging (group A,interval time<24 h;group B,interval time 24-72 h).Two neuroradiologists who were blin-ded to the patients clinical information,documented the number and location of susceptibility vessel sign (SVS)in SWI and embolic occlusion or stenosis on TOF-MRA in AIS patients.Results The thrombus detection rate in group A was higher than that in group B.There was no significant difference in the overall detection rate of thrombi between SWI and TOF-MRA in all AIS patients,but the thrombi detection rate in M3 segement of middle cerebral artery(MCA)with SWI was higher than that with TOF-MRA in group A(P <0.05).Conclusion SWI performs a high diagnostic value for thrombus detection in AIS patients,especially for the thrombus detection of M3 segement in early period of AIS.